Renoprotective effect of carbamylated darbepoetin and udenafil in ischemia-reperfusion of rat kidney due to the effect of preconditioning and inhibition of nuclear factor kappa B

Introduction: Acute kidney injury is a widespread complication in hospitalized patients, with high mortality rate and long-term complications affecting prognosis quality of life human financial costs. In addition, to date, no clear algorithm for the prevention this type damage has been developed.
 Materials methods: The research was carried out on male Wistar rats. A 40-minute renal ischemia-reperfusion model used acute injury. Further, renoprotective properties carbamylated darbepoetin, udenafil their combination were assessed based analysis biochemical studies’ results, dynamics status microvasculature, pathomorphological picture. series experiments also assess contribution adenosine triphosphate-dependent potassium channels nuclear factor kappa B said agents.
 Results discussion: Prophylactic administration darbepoetin at dose 50 μg/kg 8.7 mg/kg led statistically significant decrease creatinine blood urea nitrogen, an increase glomerular filtration simultaneous fractional excretion sodium, as well level microcirculation kidneys severity according data pathomor­phological examination all time points experiment. higher efficiency correcting ischemic reperfusion injuries observed when using pharmacological agents. glibenclamide demonstrated that its preliminary levels udenafil. ability studied agents reduce lipopolysaccharide-induced ex­pression mononuclear cells demonstrated. results suggest effects udenafil, are realized through ATP-de­pendent B.
 Conclusion: Pharmacological preconditioning reduces induced by ischemia-reperfusion.